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Erythrocytosis has been reported as a potential effect of testosterone, which can be helpful in sufferers with anemia. The best threat of erythrocytosis occurs with injectable types of testosterone in contrast with transdermal preparations, particularly in supraphysiologic doses. An increase of up to 44% of the baseline hematocrit has been reported .
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- An improve of up to 44% of the baseline hematocrit has been reported .
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Moreover, a element of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity. However, testosterone in physiologic doses could even be beneficial in sufferers with angina , have greater ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood move in males with established coronary artery disease . Therefore, an interaction of endogenous factors of the patient’s risk profile as well as the testosterone dosing may be problems with whether or not adverse events occur.
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Rhoden EL, Morgentaler A. Risks of testosterone-replacement therapy and proposals for monitoring. Testosterone alternative in hypogonadal males with angina improves ischaemic threshold and high quality of life. Ajayi AAL, Mathur R, Halushka PV. Testosterone increase human platelet thromboxane A2 receptor density and aggregation responses.
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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with traditional cardiac risk elements utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, doubtless secondary to high-dose testosterone. The affected person underwent profitable percutaneous intervention of the best coronary artery. Physicians and patients ought to be aware of the clinical consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996).
